The single most-used serum in dermatology offices for a reason. Active Serum is iS Clinical's hero — a botanical, fast-acting gel that addresses acne, fine lines, sun damage, uneven tone, and texture in one bottle. Built on a blend of salicylic acid, mandelic acid, L-arbutin, copper PCA, and bilberry extract, it resurfaces and brightens without the harshness of a traditional peel.
Most actives ask you to pick a lane — anti-aging or anti-acne. This one refuses. It clears congestion, smooths fine lines, fades post-acne marks, and brightens sun damage with the same swipe. Skin looks more even and more polished in about two weeks of nightly use.
Why we carry it
This is the bottle I recommend more than any other in the studio. If you're a client somewhere in the messy middle — aging skin that still breaks out, or acne-prone skin that's started showing fine lines — this is your bottle. We also build it into our pre-treatment protocols for ProCell and microneedling clients to prep skin and accelerate post-treatment evenness, and we send it home with lash extension clients dealing with chronic forehead breakouts from oily bangs and product transfer. It's a category-of-one serum.
Key actives
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Salicylic Acid — clears pores and reduces breakouts at the source.
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Mandelic Acid — gentle AHA for tone and resurfacing.
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L-Arbutin — safely brightens hyperpigmentation and sun damage.
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Copper PCA — supports collagen and skin renewal.
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Bilberry Extract — botanical antioxidant protection.
How to use
- After cleansing, apply 2–3 drops to face and neck on dry skin.
- Follow with moisturizer. Always layer SPF in the AM — actives increase sun sensitivity.
- Start every other night, build to nightly as tolerated.
Best for
Combination, acne-prone, and aging skin. Anyone with breakouts and fine lines at the same time. Post-acne hyperpigmentation, melasma, or sun damage.
Size: 15 ml or 30 ml
